ZM-447439 (Standard)
ZM-447439 (Standard) is the analytical standard of ZM-447439 (HY-10128) . This product is intended for research and analytical applications. ZM-447439 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.
Product Specifications
CAS Number
[331771-20-1]
Target
Apoptosis; Aurora Kinase; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(NC2=C(C(C=C3OCCCN4CCOCC4)=NC=N2)C=C3OC)C=C1)C5=CC=CC=C5
Molecular Formula
C29H31N5O4
Molecular Weight
513.59
References & Citations
[1]Ditchfield C, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol. 2003 Apr 28;161 (2) :267-80.|[2]Long ZJ, et al. ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensionalculture. Cell Cycle. 2008 May 15;7 (10) :1473-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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