AZD-1236

AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12.

Product Specifications

CAS Number

[459814-89-2]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

C[C@@]1(NC(NC1=O)=O)CS(=O)(N2CCC(CC2)OC3=CC=C(C=N3)Cl)=O

Molecular Formula

C15H19ClN4O5S

Molecular Weight

402.85

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Magnussen H, Watz H, Kirsten A, Wang M, Wray H, Samuelsson V, Mo J, Kay R. Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial. Pulm Pharmacol Ther. 2011 Oct;24 (5) :563-70.