ICI 185282
ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 -induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD2 (HY-101988), PGF2α (HY-12956), arachidonic acid (HY-109590), LTD4 and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research[1].
Product Specifications
CAS Number
106393-80-0
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(O)CCC/C=C\C[C@@H]1[C@H](C2=CC=CC=C2O)O[C@H](C(F)(F)F)OC1
Molecular Formula
C18H21F3O5
Molecular Weight
374.35
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TXA2/TP
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