Asenapine-d3,13C

Asenapine-d3,13C (Org 5222-d3,13C) is deuterium and 13C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0) . Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].

Product Specifications

CAS Number

[1217729-73-1]

Product Name Alternative

Org 5222-d3,13C

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Smiles

ClC1=CC=C(C2=C1)OC3=CC=CC=C3[C@@](C4)([H])[C@@]2([H])CN4[13C]([2H])([2H])[2H]

Molecular Formula

C16 13CH13D3ClNO

Molecular Weight

289.78

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73.|[3]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.