ICI-199441

ICI-199441 is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 can improve heart resistance to ischemia/reperfusion[1][2].

Product Specifications

CAS Number

[116508-24-8]

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Smiles

O=C(N(C)[C@@H](C1=CC=CC=C1)CN2CCCC2)CC3=CC=C(Cl)C(Cl)=C3

Molecular Formula

C21H24Cl2N2O

Molecular Weight

391.33

References & Citations

[1]Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159 (6) :718-721.|[2]Narita M, et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology. 2006 Apr;31 (4) :739-50.