Zinc Protoporphyrin (Standard)

Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn (II) -protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc Protoporphyrin has anti-cancer activity[3].

Product Specifications

CAS Number

[15442-64-5]

Product Name Alternative

Zn (II) -protoporphyrin IX (Standard) ; ZnPP (Standard) ; Zinc Protoporphyrin-9 (Standard)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Reactive Oxygen Species (ROS) ; Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Purity

97.80

Smiles

OC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O

Molecular Formula

C34H32N4O4Zn

Molecular Weight

626.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17 (4) .|[2]Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.|[3]Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.