Tetrindole (mesylate)

Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A) . Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2].

Product Specifications

CAS Number

[170964-68-8]

UNSPSC

12352005

Target

Monoamine Oxidase

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.93

Solubility

10 mM in DMSO

Smiles

CS(=O)(O)=O.N12C3=C(C4=C1C(NCC2)CCC4)C=C(C5CCCCC5)C=C3

Molecular Formula

C21H30N2O3S

Molecular Weight

390.54

References & Citations

[1]A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47 (2) :303-8.|[2]William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59.