SG2057 (Standard)
SG2057 (Standard) is the analytical standard of SG2057. This product is intended for research and analytical applications. SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent[1].
Product Specifications
CAS Number
260417-62-7
Target
ADC Payload; DNA Alkylator/Crosslinker; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1N2[C@](CC(C2)=C)([H])C=NC3=CC(OCCCCCOC4=C(OC)C=C5C(N6[C@](CC(C6)=C)([H])C=NC5=C4)=O)=C(OC)C=C13
Molecular Formula
C33H36N4O6
Molecular Weight
584.66
References & Citations
[1]John A Hartley, et al. DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Invest New Drugs. 2012 Jun;30 (3) :950-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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