YKL-05-093
YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM) . YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases[1].
Product Specifications
CAS Number
[2172616-44-1]
UNSPSC
12352005
Target
HDAC; RANKL/RANK ; Salt-inducible Kinase (SIK)
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1N(C2=CC=C(C=C2OC)OC)C3=NC(NC4=CC=C(C5CCN(CC5)C)C(OC)=C4)=NC=C3CN1C6=C(C)C=CC=C6C
Molecular Formula
C35H40N6O4
Molecular Weight
608.73
References & Citations
[1]Wein MN, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016 Oct 19;7:13176.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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