SF2523 (Standard)

SF2523 (Standard) is the analytical standard of SF2523 (HY-101146) . This product is intended for research and analytical applications. SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

Product Specifications

CAS Number

[1174428-47-7]

Target

DNA-PK; Epigenetic Reader Domain; PI3K; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4

Molecular Formula

C19H17NO5S

Molecular Weight

371.41

References & Citations

[1]Carlino L, et al. Dual Kinase-Bromodomain Inhibitors in Anticancer Drug Discovery: A Structural andPharmacological Perspective. J Med Chem. 2016 Oct 27;59 (20) :9305-9320.|[2]Andrews FH, et al. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 Feb 14;114 (7) :E1072-E1080.