Sulfo-SPDB-DM4 (Standard)
Sulfo-SPDB-DM4 (Standard) is the analytical standard of sulfo-SPDB-DM4. This product is intended for research and analytical applications. sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
Product Specifications
CAS Number
1626359-59-8
Target
Drug-Linker Conjugates for ADC; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer
Smiles
C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
Molecular Formula
C46H63ClN4O17S3
Molecular Weight
1075.66
References & Citations
[1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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