PNU-74654 (Standard)

PNU-74654 (Standard) is the analytical standard of PNU-74654 (HY-101130) . This product is intended for research and analytical applications. PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.

Product Specifications

CAS Number

[113906-27-7]

Target

Apoptosis; Reference Standards; Wnt; β-catenin

Related Pathways

Apoptosis; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3

Molecular Formula

C19H16N2O3

Molecular Weight

320.34

References & Citations

[1]Leal LF, et al. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. Oncotarget. 2015 Dec 15;6 (40) :43016-32.|[2]Trosset JY, et al. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins. 2006 Jul 1;64 (1) :60-7.