PNU-74654 (Standard)
PNU-74654 (Standard) is the analytical standard of PNU-74654. This product is intended for research and analytical applications. PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
Product Specifications
CAS Number
113906-27-7
Target
Apoptosis; Reference Standards; Wnt; β-catenin
Related Pathways
Apoptosis; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3
Molecular Formula
C19H16N2O3
Molecular Weight
320.34
References & Citations
[1]Leal LF, et al. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. Oncotarget. 2015 Dec 15;6 (40) :43016-32.|[2]Trosset JY, et al. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins. 2006 Jul 1;64 (1) :60-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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