GLP-1R Antagonist 1 (Standard)
GLP-1R Antagonist 1 (Standard) is the analytical standard of GLP-1R Antagonist 1. This product is intended for research and analytical applications. GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].
Product Specifications
CAS Number
488097-06-9
Target
GCGR; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Metabolic Disease
Smiles
O=C1C2=C(NC(C3=CC=C(Cl)C=C3)=NC2(C(F)(F)F)C(F)(F)F)N(C)C(N1C)=O
Molecular Formula
C16H11ClF6N4O2
Molecular Weight
440.73
References & Citations
[1]Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis (trifluoromethyl) -5,8-dihydropyrimido[4,5-d]pyrimidine-2,4 (1H,3H) -dione core. J. Med. Chem. 19 Jan 2017.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GA100061 1 Kit
Human Aminoacylase 1 (ACY1) activation kit by CRISPRa
Sign In for Pricing
View Details 
BNC881912-500 1x 500 µL
ROR2 (ROR2/1912), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNUM1959-50 1x 50 µL
Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker) (KRT19/1959R), 1mg/mL
Sign In for Pricing
View Details