GLP-1R Antagonist 1 (Standard)
GLP-1R Antagonist 1 (Standard) is the analytical standard of GLP-1R Antagonist 1. This product is intended for research and analytical applications. GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].
Product Specifications
CAS Number
488097-06-9
Target
GCGR; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Metabolic Disease
Smiles
O=C1C2=C(NC(C3=CC=C(Cl)C=C3)=NC2(C(F)(F)F)C(F)(F)F)N(C)C(N1C)=O
Molecular Formula
C16H11ClF6N4O2
Molecular Weight
440.73
References & Citations
[1]Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis (trifluoromethyl) -5,8-dihydropyrimido[4,5-d]pyrimidine-2,4 (1H,3H) -dione core. J. Med. Chem. 19 Jan 2017.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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