PF-06840003 (Standard)
PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111) . This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively[1][2].
Product Specifications
CAS Number
[198474-05-4]
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O
Molecular Formula
C12H9FN2O2
Molecular Weight
232.21
References & Citations
[1]Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA) : AACR; Cancer Res 2016;76 (14 Suppl) :Abstract nr4863.|[2]Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3- (5-Fluoro-1H-indol-3-yl) pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem. 2017 Dec 14;60 (23) :9617-9629.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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