AR7 (Standard)
AR7 (Standard) is the analytical standard of AR7. This product is intended for research and analytical applications. AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].
Product Specifications
CAS Number
80306-38-3
Target
RAR/RXR; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Neurological Disease
Smiles
CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
Molecular Formula
C15H12ClNO
Molecular Weight
257.71
References & Citations
[1]Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9 (6) :374-82.|[2]Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA) . Autophagy. 2020 Feb;16 (2) :347-370.|[3]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184 (10) :2696-2714.e25.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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