SB-224289 (hydrochloride) (Standard)
SB-224289 (hydrochloride) (Standard) is the analytical standard of SB-224289 (hydrochloride) (HY-101105A) . This product is intended for research and analytical applications. SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
Product Specifications
CAS Number
[180084-26-8]
Target
5-HT Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)N4CCC5=C4C=C6C(OCC67CCN(C)CC7)=C5.Cl
Molecular Formula
C32H33ClN4O3
Molecular Weight
557.08
References & Citations
[1]Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11 (5) :e0154932.|[2]Hoplight BJ, et al. The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. Physiol Behav. 2005 Apr 13;84 (5) :707-14. Epub 2005 Apr 13.|[3]Gaster LM, et al. The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. Ann N Y Acad Sci. 1998 Dec 15;861:270-1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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