AS-605240 (Standard)
AS-605240 (Standard) is the analytical standard of AS-605240 (HY-10109) . This product is intended for research and analytical applications. AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC50 of 8 nM, and a Ki of 7.8 nM.
Product Specifications
CAS Number
[648450-29-7]
Target
Autophagy; PI3K; Reference Standards
Related Pathways
Autophagy; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NC/1=O)SC1=C/C2=CC=C3N=CC=NC3=C2
Molecular Formula
C12H7N3O2S
Molecular Weight
257.27
References & Citations
[1]Huang X, et al. Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury. Circulation. 2016 Mar 15;133 (11) :1093-103.|[2]Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11 (9) :936-43.|[3]Azzi J, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61 (6) :1509-18. Epub 2012 Mar 8.|[4]Wei X, et al. A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun. 2010 Jun 25;397 (2) :311-7. Epub 2010 May 26.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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