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AS-605240 (Standard)

AS-605240 (Standard) is the analytical standard of AS-605240. This product is intended for research and analytical applications. AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC50 of 8 nM, and a Ki of 7.8 nM.

Product Specifications

CAS Number

648450-29-7

Target

Autophagy; PI3K; Reference Standards

Related Pathways

Autophagy; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(NC/1=O)SC1=C/C2=CC=C3N=CC=NC3=C2

Molecular Formula

C12H7N3O2S

Molecular Weight

257.27

References & Citations

[1]Huang X, et al. Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury. Circulation. 2016 Mar 15;133 (11) :1093-103.|[2]Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11 (9) :936-43.|[3]Azzi J, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61 (6) :1509-18. Epub 2012 Mar 8.|[4]Wei X, et al. A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun. 2010 Jun 25;397 (2) :311-7. Epub 2010 May 26.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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