AS-605240 (potassium)
AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC50: 8 nM; Ki: 7.8 nM) . AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC50 values are 0.181 and 0.550 µM, respectively) . AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5) - and thioglycolate-induced peritonitis mouse models (EC50 values are 9.1 and 10 mg/kg, respectively) . AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice[1].
Product Specifications
UNSPSC
12352005
Target
Akt; PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Smiles
O=C([N-]C/1=O)SC1=C/C2=CC3=C(N=CC=N3)C=C2.[K+]
Molecular Formula
C12H6KN3O2S
Molecular Weight
295.36
References & Citations
[1]Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11 (9) :936-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ
Curated Selection
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