AS-605240 (potassium)

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC50: 8 nM; Ki: 7.8 nM) . AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC50 values are 0.181 and 0.550 µM, respectively) . AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5) - and thioglycolate-induced peritonitis mouse models (EC50 values are 9.1 and 10 mg/kg, respectively) . AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice[1].