Ocaperidone (Standard)

Ocaperidone (Standard) is the analytical standard of Ocaperidone (HY-101094) . This product is intended for research and analytical applications. Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.

Product Specifications

CAS Number

[129029-23-8]

Target

5-HT Receptor; Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C1C(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)=C(C)N=C5N1C=CC=C5C

Molecular Formula

C24H25FN4O2

Molecular Weight

420.48

References & Citations

[1]Leysen JE, et al. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol Pharmacol. 1992 Mar;41 (3) :494-508.|[2]Cosi C, et al. Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT (1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433 (1) :55-62.|[3]Rijnders HJ, et al. The discriminative stimulus properties of buspirone involve dopamine-2 receptor antagonist activity. Psychopharmacology (Berl) . 1993;111 (1) :55-61.