LY294002 (Standard)

LY294002 (Standard) is the analytical standard of LY294002. This product is intended for research and analytical applications. LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4?μM. LY294002 is an apoptosis activator[3].

Product Specifications

CAS Number

[154447-36-6]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Casein Kinase; DNA-PK; PI3K; Reference Standards

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Infection

Smiles

O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4

Molecular Formula

C19H17NO3

Molecular Weight

307.34

References & Citations

[1]Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms. Biochem J. 2007 Jun 15;404 (3) :449-58.|[2]Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404 (1) :15-21.|[3]Davidson D, et al. Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond. Front Pharmacol. 2013 Jan 31;4:5.|[4]Jiang H, et al. Phosphatidylinositol 3-kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma invitro and in vivo. J Exp Clin Cancer Res. 2010 Apr 22;29:34.|[5]Md Mokhtar AH, et al. LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats. Andrologia. 2019 Apr;51 (3) :e13196.|[6]Yi-Jen Hsueh, et al. Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol Ther Methods Clin Dev. 2015 Apr 29;2:15014.