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LY294002 (hydrochloride) (Standard)

LY294002 (hydrochloride) (Standard) is the analytical standard of LY294002 (hydrochloride) . This product is intended for research and analytical applications. LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research[1][2][3].

Product Specifications

CAS Number

934389-88-5

UNSPSC

12352005

Target

Apoptosis; Casein Kinase; DNA-PK; PI3K; Reference Standards

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4.Cl

Molecular Formula

C19H18ClNO3

Molecular Weight

343.80

References & Citations

[1]Bai R, et al. The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo. Neoplasma. 2016;63 (1) :80-92.|[2]Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404 (3) :449-58.|[3]Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404 (1) :15-21.|[4]Jiang H, et al. Phosphatidylinositol 3-kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma invitro and in vivo. J Exp Clin Cancer Res. 2010 Apr 22;29:34.|[5]Md Mokhtar AH, et al. LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats. Andrologia. 2019 Apr;51 (3) :e13196.|[6]Yi-Jen Hsueh, et al. Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol Ther Methods Clin Dev. 2015 Apr 29;2:15014.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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