SKL2001 (Standard)

SKL2001 (Standard) is the analytical standard of SKL2001 (HY-101085) . This product is intended for research and analytical applications. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].

Product Specifications

CAS Number

[909089-13-0]

Target

Reference Standards; Wnt; β-catenin

Related Pathways

Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3

Molecular Formula

C14H14N4O3

Molecular Weight

286.29

References & Citations

[1]Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22 (1) :237-47.|[2]Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493 (3) :1342-1348.