SKL2001 (Standard)
SKL2001 (Standard) is the analytical standard of SKL2001. This product is intended for research and analytical applications. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].
Product Specifications
CAS Number
909089-13-0
Target
Reference Standards; Wnt; β-catenin
Related Pathways
Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
Molecular Formula
C14H14N4O3
Molecular Weight
286.29
References & Citations
[1]Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22 (1) :237-47.|[2]Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493 (3) :1342-1348.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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