NSC 228155 (Standard)

NSC 228155 (Standard) is the analytical standard of NSC 228155 (HY-101084) . This product is intended for research and analytical applications. NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].

Product Specifications

CAS Number

[113104-25-9]

Target

EGFR; Epigenetic Reader Domain; Histone Acetyltransferase; Reference Standards

Related Pathways

Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32

Molecular Formula

C11H6N4O4S

Molecular Weight

290.25

References & Citations

[1]Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088.|[2]Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23 (19) :5371-5.