Iso-PPADS (tetrasodium)

Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI) [1][2].

Product Specifications

CAS Number

[207572-67-6]

UNSPSC

12352005

Target

P2X Receptor

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(S(=O)(O[Na])=O)C=C1/N=N/C2=NC(C)=C(O)C(C=O)=C2COP(O[Na])(O[Na])=O)(O[Na])=O

Molecular Formula

C14H10N3Na4O12PS2

Molecular Weight

599.30

References & Citations

[1]González-López A, et al. Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. Crit Care Med. 2019 Nov;47 (11) :e911-e918.|[2]Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53 (4) :281-291.