Monastrol (Standard)

Monastrol (Standard) is the analytical standard of Monastrol (HY-101071A) . This product is intended for research and analytical applications. Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.

Product Specifications

CAS Number

[329689-23-8]

Target

Apoptosis; Kinesin; Reference Standards

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others

Field of Research

Cancer

Smiles

O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC

Molecular Formula

C14H16N2O3S

Molecular Weight

292.36

References & Citations

[1]Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280 (13) :12658-67.|[2]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389 (12) :1279-1288.|[3]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286 (5441) :971-4.