Monastrol (Standard)
Monastrol (Standard) is the analytical standard of Monastrol. This product is intended for research and analytical applications. Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
Product Specifications
CAS Number
329689-23-8
Target
Apoptosis; Kinesin; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others
Field of Research
Cancer
Smiles
O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC
Molecular Formula
C14H16N2O3S
Molecular Weight
292.36
References & Citations
[1]Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280 (13) :12658-67.|[2]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389 (12) :1279-1288.|[3]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286 (5441) :971-4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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