TOFA (Standard)
TOFA (Standard) is the analytical standard of TOFA. This product is intended for research and analytical applications. TOFA (RMI14514; MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
Product Specifications
CAS Number
54857-86-2
Target
Acetyl-CoA Carboxylase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)O
Molecular Formula
C19H32O4
Molecular Weight
324.45
References & Citations
[1]Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385 (3) :302-6.|[2]Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8 (2) :373-8.|[3]Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12 (1) :80-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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