GSK 4027 (Standard)

GSK 4027 (Standard) is the analytical standard of GSK 4027 (HY-101027) . This product is intended for research and analytical applications. GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

Product Specifications

CAS Number

[2079896-25-4]

Target

Epigenetic Reader Domain; Histone Acetyltransferase; Reference Standards

Related Pathways

Epigenetics; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

BrC1=C(N[C@@H]2C[C@H](C3=CC=CC=C3)CN(C)C2)C=NN(C)C1=O

Molecular Formula

C17H21BrN4O

Molecular Weight

377.28

References & Citations

[1]Humphreys PG, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF) /General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60 (2) :695-709.