MK-8617 (Standard)
MK-8617 (Standard) is the analytical standard of MK-8617. This product is intended for research and analytical applications. MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
Product Specifications
CAS Number
1187990-87-9
Target
HIF/HIF Prolyl-Hydroxylase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
References & Citations
[1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-A189325-1G 1 g
1-O-Acetyl-2,3,5-tri-O-benzoyl-Alpha,Beta-D-ribofuranose
Sign In for Pricing
View Details 
LC421777 20 µg
SSX4 (SSX4B) (NM_001040612) Human Over-expression Lysate
Sign In for Pricing
View Details 
PKSH033609-01 10 µg
Recombinant Human IL7RA/CD127 Protein (Fc & His Tag)
Sign In for Pricing
View Details