10074-G5 (Standard)
10074-G5 (Standard) is the analytical standard of 10074-G5 (HY-100996) . This product is intended for research and analytical applications. 10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
Product Specifications
CAS Number
[413611-93-5]
Target
Autophagy; c-Myc; Reference Standards
Related Pathways
Apoptosis; Autophagy; Others
Field of Research
Cancer
Smiles
O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41
Molecular Formula
C18H12N4O3
Molecular Weight
332.31
References & Citations
[1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335 (3) :715-27.|[2]Chauhan J, et al. Discovery of methyl 4'-methyl-5- (7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) -[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9 (10) :2274-85.|[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :370-4.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100996R/
Scientific Category
Reference Standards
Curated Selection
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