10074-G5 (Standard)

10074-G5 (Standard) is the analytical standard of 10074-G5 (HY-100996) . This product is intended for research and analytical applications. 10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.

Product Specifications

CAS Number

[413611-93-5]

Target

Autophagy; c-Myc; Reference Standards

Related Pathways

Apoptosis; Autophagy; Others

Field of Research

Cancer

Smiles

O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41

Molecular Formula

C18H12N4O3

Molecular Weight

332.31

References & Citations

[1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335 (3) :715-27.|[2]Chauhan J, et al. Discovery of methyl 4'-methyl-5- (7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) -[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9 (10) :2274-85.|[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :370-4.