HA-100 (Standard)
HA-100 (Standard) is the analytical standard of HA-100. This product is intended for research and analytical applications. HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor[1][2].
Product Specifications
CAS Number
84468-24-6
Target
Myosin; PKA; PKC; Reference Standards; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O
Molecular Formula
C13H15N3O2S
Molecular Weight
277.34
References & Citations
[1]Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32 (1) :7-12.|[2]Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6 (3) :e17557.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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