ARV-771 (Standard)
ARV-771 (Standard) is the analytical standard of ARV-771. This product is intended for research and analytical applications. ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1), and BRD4 (2), respectively[1].
Product Specifications
CAS Number
1949837-12-0
Target
Epigenetic Reader Domain; PROTACs; Reference Standards
Related Pathways
Epigenetics; Others; PROTAC
Field of Research
Cancer
Smiles
CC(C(C(C1=CC=C(Cl)C=C1)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C2)[C@@H]2C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C
Molecular Formula
C49H60ClN9O7S2
Molecular Weight
986.64
References & Citations
[1]Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113 (26) :7124-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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