3,5-Dinitrocatechol (Standard)

3,5-Dinitrocatechol (Standard) is the analytical standard of 3,5-Dinitrocatechol. This product is intended for research and analytical applications. 3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI) - 3,5-Dinitrocatechol complex[1][2][3].

Product Specifications

CAS Number

[7659-29-2]

Product Name Alternative

OR-486 (Standard) ; 3,5-Dinitropyrocatechol (Standard)

UNSPSC

12352005

Target

COMT; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O

Molecular Formula

C6H4N2O6

Molecular Weight

200.11

References & Citations

[1]Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153 (2-3) :263-9. |[2]Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43 (3) :493-502. |[3]Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum (VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63 (3) :654-60.