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ABC1183 (Standard)

ABC1183 (Standard) is the analytical standard of ABC1183. This product is intended for research and analytical applications. ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities[1].

Product Specifications

CAS Number

1042735-18-1

Target

CDK; GSK-3; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Smiles

N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1

Molecular Formula

C18H14N4OS

Molecular Weight

334.39

References & Citations

[1]Randy S Schrecengost, et al. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365 (1) :107-116.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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