VH-298 (Standard)
VH-298 (Standard) is the analytical standard of VH-298 (HY-100947) . This product is intended for research and analytical applications. VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM. VH-298 leads to HIF-α accumulation inside HeLa cells. VH-298 is an E3 ligase Ligand, and can be used for synthesis of PROTACs[1].
Product Specifications
CAS Number
[2097381-85-4]
Target
HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
References & Citations
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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