CEP-40783 (Standard)
CEP-40783 (Standard) is the analytical standard of CEP-40783 (HY-100946) . This product is intended for research and analytical applications. CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.
Product Specifications
CAS Number
[1437321-24-8]
Target
C-Met/HGFR; Reference Standards; TAM Receptor
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CN(C(C)C)C(N(C2=CC=C(F)C=C2)C1=O)=O)NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C45)C(F)=C3
Molecular Formula
C31H26F2N4O6
Molecular Weight
588.56
References & Citations
[1]Sheila M, et al. CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA) : AACR; Mol Cancer Ther 2013;12 (11 Suppl) :Abstract nr C275.|[2]Jay F, et al. Antitumor activity of the dual AXL/c-Met inhibitor CEP-40783 in Champions primary TumorGraft? models of human non-small cell lung cancer (NSCLC) . [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA) : AACR; Mol Cancer Ther 2013;12 (11 Suppl) :Abstract nr C272.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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