CCCP (Standard)

CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

Product Specifications

CAS Number

[555-60-2]

Product Name Alternative

Carbonyl cyanide 3-chlorophenylhydrazone (Standard) ; Carbonyl Cyanide m-Chlorophenylhydrazone (Standard)

UNSPSC

12352005

Target

Apoptosis; Bacterial; IFNAR; Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin; Reference Standards; STING

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Cancer; Inflammation/Immunology

Purity

99.14

Smiles

N#C/C(C#N)=N/NC1=CC=CC(Cl)=C1

Molecular Formula

C9H5ClN4

Molecular Weight

204.62

References & Citations

[1]Kwon D, et al. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017 Aug 30. pii: S0006-291X (17) 31704-7.|[2]Sinha D, et al. Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazonecombination against MDR bacterial strains. Sci Rep. 2017 Mar 17;7:44419.|[3]Kawamoto A, et al. Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure. PLoS One. 2015 Jan 16;10 (1) :e0117091.|[4]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2 (5) :120080.|[5]Haifeng Jiao, et al. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021 May 27;184 (11) :2896-2910.e13.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

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