ML-9 (Standard)
ML-9 (Standard) is the analytical standard of ML-9. This product is intended for research and analytical applications. ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
Product Specifications
CAS Number
105637-50-1
Target
Myosin; Reference Standards
Related Pathways
Cytoskeleton; Others
Field of Research
Cancer
Smiles
O=S(N1CCNCCC1)(C2=C3C=CC=C(Cl)C3=CC=C2)=O.[H]Cl
Molecular Formula
C15H18Cl2N2O2S
Molecular Weight
361.29
References & Citations
[1]Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486 (3) :325-33.|[2]Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.|[3]Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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