Ro 20-1724 (Standard)

Ro 20-1724 (Standard) is the analytical standard of Ro 20-1724. This product is intended for research and analytical applications. Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].

Product Specifications

CAS Number

[29925-17-5]

Product Name Alternative

Ro 20-174 (Standard)

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease

Smiles

O=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1

Molecular Formula

C15H22N2O3

Molecular Weight

278.35

References & Citations

[1]Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4- (3-butoxy-4-methoxybenzyl) imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38 (24) :4848-4854. |[2]Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101 (2) :239-245.