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Ambenonium (chloride) (Standard)

Ambenonium (chloride) (Standard) is the analytical standard of Ambenonium (chloride) . This product is intended for research and analytical applications. Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE) [1][2].

Product Specifications

CAS Number

115-79-7

Product Name Alternative

WIN 8077 (chloride) (Standard)

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Others

Smiles

O=C(NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)C(NCC[N+](CC)(CC)CC2=CC=CC=C2Cl)=O.[Cl-].[Cl-]

Molecular Formula

C28H42Cl4N4O2

Molecular Weight

608.47

References & Citations

[1]Hodge AS, et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol. 1992 May. 41 (5) :937-42.|[2]Komloova M, et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett. 2011 Apr 15. 21 (8) :2505-9.|[3]Hazama R, et al. Effects of long-term administration of ambenonium chloride on motor end-plate fine structure and acetylcholine receptor in rat. J Neurol Sci. 1981 Jul. 51 (1) :69-79.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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