OGT 2115 (Standard)

OGT 2115 (Standard) is the analytical standard of OGT 2115 (HY-100898) . This product is intended for research and analytical applications. OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM) . OGT 2115 also inhibits heparan sulfate degradation activity[1][2].

Product Specifications

CAS Number

[853929-59-6]

Target

Glycosidase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(O)CC1=CC=C(OC(C2=CC=C(NC(/C=C/C3=CC=C(Br)C=C3)=O)C(F)=C2)=N4)C4=C1

Molecular Formula

C24H16BrFN2O4

Molecular Weight

495.30

References & Citations

[1][1]Courtney SM, et al. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett. 2005 May 2;15 (9) :2295-9.|[2]Li Y, et al. Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase. Int J Mol Med. 2013 May;31 (5) :1234-42.