BAY1082439 (Standard)
BAY1082439 (Standard) is the analytical standard of BAY1082439. This product is intended for research and analytical applications. BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].
Product Specifications
CAS Number
1375469-38-7
Target
Apoptosis; PI3K; Reference Standards
Related Pathways
Apoptosis; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C1=CC=CN=C1C)NC2=NC3=C(C=CC(OC[C@H](O)CN4CCOCC4)=C3OC)C5=NCCN25
Molecular Formula
C25H30N6O5
Molecular Weight
494.54
References & Citations
[1]Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.|[2]Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17 (10) :2091-2099.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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