BAY1082439 (Standard)

BAY1082439 (Standard) is the analytical standard of BAY1082439 (HY-100886) . This product is intended for research and analytical applications. BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].

Product Specifications

CAS Number

[1375469-38-7]

Target

Apoptosis; PI3K; Reference Standards

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(C1=CC=CN=C1C)NC2=NC3=C(C=CC(OC[C@H](O)CN4CCOCC4)=C3OC)C5=NCCN25

Molecular Formula

C25H30N6O5

Molecular Weight

494.54

References & Citations

[1]Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.|[2]Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17 (10) :2091-2099.