Bisantrene (Standard)
Bisantrene (Standard) is the analytical standard of Bisantrene. This product is intended for research and analytical applications. Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1[1][2][3][4].
Product Specifications
CAS Number
78186-34-2
Product Name Alternative
CL216942 (Standard)
UNSPSC
12352005
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5
Molecular Formula
C22H22N8
Molecular Weight
398.46
References & Citations
[1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54 (6) :1036-45.|[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43 (3) :1402-4.|[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[ (4,5-dihydro-1H-imidazole-2-yl) hydrazone] dihydrochloride (bisantrene) . Cancer Res. 1984 Jun;44 (6) :2363-7. |[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2 (6) :973-80.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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