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Bisantrene (dihydrochloride) (Standard)

Bisantrene (dihydrochloride) (Standard) is the analytical standard of Bisantrene (dihydrochloride). This product is intended for research and analytical applications. Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].

Product Specifications

CAS Number

71439-68-4

Target

Reference Standards; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

[H]Cl.[H]Cl.C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5

Molecular Formula

C22H24Cl2N8

Molecular Weight

471.39

References & Citations

[1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54 (6) :1036-45.|[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43 (3) :1402-4.|[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[ (4,5-dihydro-1H-imidazole-2-yl) hydrazone] dihydrochloride (bisantrene) . Cancer Res. 1984 Jun;44 (6) :2363-7. |[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2 (6) :973-80.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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