WT-161 (Standard)
WT-161 (Standard) is the analytical standard of WT-161. This product is intended for research and analytical applications. WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM[1]. WT-161 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
Product Specifications
CAS Number
1206731-57-8
Target
Apoptosis; Beta-lactamase; HDAC; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)CCCCCCC(NO)=O
Molecular Formula
C27H30N4O3
Molecular Weight
458.55
References & Citations
[1]Hideshima T, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A. 2016 Nov 15;113 (46) :13162-13167.|[2]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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