GS-444217 (Standard)
GS-444217 (Standard) is the analytical standard of GS-444217 (HY-100844) . This product is intended for research and analytical applications. GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM[1].
Product Specifications
CAS Number
[1262041-49-5]
Target
Apoptosis; MAP3K; Reference Standards
Related Pathways
Apoptosis; MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
O=C(C1=NC=CC(N2C=C(C3CC3)N=C2)=C1)NC4=CC=CC(C5=NN=CN5C6CC6)=C4
Molecular Formula
C23H21N7O
Molecular Weight
411.46
References & Citations
[1]Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128 (10) :4485-4500.|[2]Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197 (3) :373-385.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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